Ultraviolet radiation exposure and risk of malignant lymphomas
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Ultraviolet radiation exposure and risk of malignant lymphomas. / Smedby, Karin Ekström; Hjalgrim, Henrik; Melbye, Mads; Torrång, Anna; Rostgaard, Klaus; Munksgaard, Lars; Adami, Johanna; Hansen, Mads; Porwit-MacDonald, Anna; Jensen, Bjarne Anker; Roos, Göran; Pedersen, Bjarne Bach; Sundström, Christer; Glimelius, Bengt; Adami, Hans Olov.
I: Journal of the National Cancer Institute, Bind 97, Nr. 3, 02.02.2005, s. 199-209.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Ultraviolet radiation exposure and risk of malignant lymphomas
AU - Smedby, Karin Ekström
AU - Hjalgrim, Henrik
AU - Melbye, Mads
AU - Torrång, Anna
AU - Rostgaard, Klaus
AU - Munksgaard, Lars
AU - Adami, Johanna
AU - Hansen, Mads
AU - Porwit-MacDonald, Anna
AU - Jensen, Bjarne Anker
AU - Roos, Göran
AU - Pedersen, Bjarne Bach
AU - Sundström, Christer
AU - Glimelius, Bengt
AU - Adami, Hans Olov
PY - 2005/2/2
Y1 - 2005/2/2
N2 - Background: The incidence of malignant lymphomas has been increasing rapidly, but the causes of these malignancies remain poorly understood. One hypothesis holds that exposure to ultraviolet (UV) radiation increases lymphoma risk. We tested this hypothesis in a population-based case-control study in Denmark and Sweden. Methods: A total of 3740 patients diagnosed between October 1, 1999, and August 30, 2002, with incident malignant lymphomas, including non-Hodgkin lymphoma, chronic lymphocytic leukemia, and Hodgkin lymphoma, and 3187 population controls provided detailed information on history of UV exposure and skin cancer and information on other possible risk factors for lymphomas. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by logistic regression. Statistical tests were two-sided. Results: Multivariable-adjusted analyses revealed consistent, statistically significant negative associations between various measures of UV light exposure and risk of non-Hodgkin lymphoma. A high frequency of sun bathing and sunburns at age 20 years and 5-10 years before the interview and sun vacations abroad were associated with 30%-40% reduced risks of non-Hodgkin lymphoma (e.g., for sunbathing four times a week or more at age 20 versus never sunbathing, OR = 0.7, 95% CI = 0.6 to 0.9; for two or more sunburns a year at age 20 versus no sunburns, OR = 0.6, 95% CI = 0.5 to 0.8). These inverse associations increased in strength with increasing levels of exposure (all Ptrend≤.01). Similar, albeit weaker, associations were observed for Hodgkin lymphoma. There were no clear differences among non-Hodgkin lymphoma subtypes, although associations were stronger for B-cell than for T-cell lymphomas. A history of skin cancer was associated with a doubling in risks of both non-Hodgkin and Hodgkin lymphoma. Conclusions: A history of high UV exposure was associated with reduced risk of non-Hodgkin lymphoma. The positive association between skin cancer and malignant lymphomas is, therefore, unlikely to be mediated by UV exposure.
AB - Background: The incidence of malignant lymphomas has been increasing rapidly, but the causes of these malignancies remain poorly understood. One hypothesis holds that exposure to ultraviolet (UV) radiation increases lymphoma risk. We tested this hypothesis in a population-based case-control study in Denmark and Sweden. Methods: A total of 3740 patients diagnosed between October 1, 1999, and August 30, 2002, with incident malignant lymphomas, including non-Hodgkin lymphoma, chronic lymphocytic leukemia, and Hodgkin lymphoma, and 3187 population controls provided detailed information on history of UV exposure and skin cancer and information on other possible risk factors for lymphomas. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by logistic regression. Statistical tests were two-sided. Results: Multivariable-adjusted analyses revealed consistent, statistically significant negative associations between various measures of UV light exposure and risk of non-Hodgkin lymphoma. A high frequency of sun bathing and sunburns at age 20 years and 5-10 years before the interview and sun vacations abroad were associated with 30%-40% reduced risks of non-Hodgkin lymphoma (e.g., for sunbathing four times a week or more at age 20 versus never sunbathing, OR = 0.7, 95% CI = 0.6 to 0.9; for two or more sunburns a year at age 20 versus no sunburns, OR = 0.6, 95% CI = 0.5 to 0.8). These inverse associations increased in strength with increasing levels of exposure (all Ptrend≤.01). Similar, albeit weaker, associations were observed for Hodgkin lymphoma. There were no clear differences among non-Hodgkin lymphoma subtypes, although associations were stronger for B-cell than for T-cell lymphomas. A history of skin cancer was associated with a doubling in risks of both non-Hodgkin and Hodgkin lymphoma. Conclusions: A history of high UV exposure was associated with reduced risk of non-Hodgkin lymphoma. The positive association between skin cancer and malignant lymphomas is, therefore, unlikely to be mediated by UV exposure.
UR - http://www.scopus.com/inward/record.url?scp=13744258994&partnerID=8YFLogxK
U2 - 10.1093/jnci/dji022
DO - 10.1093/jnci/dji022
M3 - Journal article
C2 - 15687363
AN - SCOPUS:13744258994
VL - 97
SP - 199
EP - 209
JO - National Cancer Institute. Journal (Online)
JF - National Cancer Institute. Journal (Online)
SN - 1460-2105
IS - 3
ER -
ID: 259459270