Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Katherine L Musliner
  • Klaus K. Andersen
  • Esben Agerbo
  • Clara Albiñana
  • Bjarni J Vilhjalmsson
  • Veera M Rajagopal
  • Jonas Bybjerg-Grauholm
  • Marie Bækved-Hansen
  • Carsten B. Pedersen
  • Marianne G. Pedersen
  • Trine Munk-Olsen
  • Benros, Michael Eriksen
  • Thomas D Als
  • Jakob Grove
  • Werge, Thomas
  • Anders D Børglum
  • David M Hougaard
  • Ole Mors
  • Nordentoft, Merete
  • Preben B Mortensen
  • Nis P Suppli
  • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

BACKGROUND: In this study, we examined the relationship between polygenic liability for depression and number of stressful life events (SLEs) as risk factors for early-onset depression treated in inpatient, outpatient or emergency room settings at psychiatric hospitals in Denmark.

METHODS: Data were drawn from the iPSYCH2012 case-cohort sample, a population-based sample of individuals born in Denmark between 1981 and 2005. The sample included 18 532 individuals who were diagnosed with depression by a psychiatrist by age 31 years, and a comparison group of 20 184 individuals. Information on SLEs was obtained from nationwide registers and operationalized as a time-varying count variable. Hazard ratios and cumulative incidence rates were estimated using Cox regressions.

RESULTS: Risk for depression increased by 35% with each standard deviation increase in polygenic liability (p < 0.0001), and 36% (p < 0.0001) with each additional SLE. There was a small interaction between polygenic liability and SLEs (β = -0.04, p = 0.0009). The probability of being diagnosed with depression in a hospital-based setting between ages 15 and 31 years ranged from 1.5% among males in the lowest quartile of polygenic liability with 0 events by age 15, to 18.8% among females in the highest quartile of polygenic liability with 4+ events by age 15.

CONCLUSIONS: These findings suggest that although there is minimal interaction between polygenic liability and SLEs as risk factors for hospital-treated depression, combining information on these two important risk factors could potentially be useful for identifying high-risk individuals.

TidsskriftPsychological Medicine
Antal sider10
StatusE-pub ahead of print - 5 maj 2021

ID: 270573491