Mannose-binding lectin polymorphisms in clinical tuberculosis

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Standard

Mannose-binding lectin polymorphisms in clinical tuberculosis. / Søborg, Christian; Madsen, Hans O.; Andersen, Åse B.; Lillebaek, Troels; Kok-Jensen, Axel; Garred, Peter.

I: Journal of Infectious Diseases, Bind 188, Nr. 5, 01.09.2003, s. 777-782.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Søborg, C, Madsen, HO, Andersen, ÅB, Lillebaek, T, Kok-Jensen, A & Garred, P 2003, 'Mannose-binding lectin polymorphisms in clinical tuberculosis', Journal of Infectious Diseases, bind 188, nr. 5, s. 777-782. https://doi.org/10.1086/377183

APA

Søborg, C., Madsen, H. O., Andersen, Å. B., Lillebaek, T., Kok-Jensen, A., & Garred, P. (2003). Mannose-binding lectin polymorphisms in clinical tuberculosis. Journal of Infectious Diseases, 188(5), 777-782. https://doi.org/10.1086/377183

Vancouver

Søborg C, Madsen HO, Andersen ÅB, Lillebaek T, Kok-Jensen A, Garred P. Mannose-binding lectin polymorphisms in clinical tuberculosis. Journal of Infectious Diseases. 2003 sep. 1;188(5):777-782. https://doi.org/10.1086/377183

Author

Søborg, Christian ; Madsen, Hans O. ; Andersen, Åse B. ; Lillebaek, Troels ; Kok-Jensen, Axel ; Garred, Peter. / Mannose-binding lectin polymorphisms in clinical tuberculosis. I: Journal of Infectious Diseases. 2003 ; Bind 188, Nr. 5. s. 777-782.

Bibtex

@article{d7e4f98c1c864105929ce23832029cca,
title = "Mannose-binding lectin polymorphisms in clinical tuberculosis",
abstract = "Mannose-binding lectin (MBL) mediates protection against infections by using the complement system, but certain microorganisms may increase infectivity by exploiting this host defense system. Thus, it has been speculated whether genetically determined low MBL levels may confer partial protection against certain intracellular microorganisms, such as Mycobacterium tuberculosis. We investigated MBL alleles in 109 culture-positive human immunodeficiency virus-uninfected patients with tuberculosis living in Denmark and 250 white control subjects. Patients and control subjects were divided into 3 different groups defined by undetectable, low, and high serum MBL concentrations, which correlates to deficient, low, and high expressing MBL genotypes. A significantly decreased frequency of patients with the low-expressing MBL genotype was observed in white patients compared to control subjects. The same tendency also was observed in patients of other ethnic origin. It may be hypothesized that heterozygosity for MBL variant alleles, which encodes low serum MBL levels, is associated with protection against clinical tuberculosis.",
author = "Christian S{\o}borg and Madsen, {Hans O.} and Andersen, {{\AA}se B.} and Troels Lillebaek and Axel Kok-Jensen and Peter Garred",
year = "2003",
month = sep,
day = "1",
doi = "10.1086/377183",
language = "English",
volume = "188",
pages = "777--782",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Mannose-binding lectin polymorphisms in clinical tuberculosis

AU - Søborg, Christian

AU - Madsen, Hans O.

AU - Andersen, Åse B.

AU - Lillebaek, Troels

AU - Kok-Jensen, Axel

AU - Garred, Peter

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Mannose-binding lectin (MBL) mediates protection against infections by using the complement system, but certain microorganisms may increase infectivity by exploiting this host defense system. Thus, it has been speculated whether genetically determined low MBL levels may confer partial protection against certain intracellular microorganisms, such as Mycobacterium tuberculosis. We investigated MBL alleles in 109 culture-positive human immunodeficiency virus-uninfected patients with tuberculosis living in Denmark and 250 white control subjects. Patients and control subjects were divided into 3 different groups defined by undetectable, low, and high serum MBL concentrations, which correlates to deficient, low, and high expressing MBL genotypes. A significantly decreased frequency of patients with the low-expressing MBL genotype was observed in white patients compared to control subjects. The same tendency also was observed in patients of other ethnic origin. It may be hypothesized that heterozygosity for MBL variant alleles, which encodes low serum MBL levels, is associated with protection against clinical tuberculosis.

AB - Mannose-binding lectin (MBL) mediates protection against infections by using the complement system, but certain microorganisms may increase infectivity by exploiting this host defense system. Thus, it has been speculated whether genetically determined low MBL levels may confer partial protection against certain intracellular microorganisms, such as Mycobacterium tuberculosis. We investigated MBL alleles in 109 culture-positive human immunodeficiency virus-uninfected patients with tuberculosis living in Denmark and 250 white control subjects. Patients and control subjects were divided into 3 different groups defined by undetectable, low, and high serum MBL concentrations, which correlates to deficient, low, and high expressing MBL genotypes. A significantly decreased frequency of patients with the low-expressing MBL genotype was observed in white patients compared to control subjects. The same tendency also was observed in patients of other ethnic origin. It may be hypothesized that heterozygosity for MBL variant alleles, which encodes low serum MBL levels, is associated with protection against clinical tuberculosis.

UR - http://www.scopus.com/inward/record.url?scp=0141724527&partnerID=8YFLogxK

U2 - 10.1086/377183

DO - 10.1086/377183

M3 - Journal article

C2 - 12934195

AN - SCOPUS:0141724527

VL - 188

SP - 777

EP - 782

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 5

ER -

ID: 247166195