Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

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Standard

Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load. / Lyngse, Frederik Plesner; Mølbak, Kåre; Skov, Robert Leo; Christiansen, Lasse Engbo; Mortensen, Laust Hvas; Albertsen, Mads; Møller, Camilla Holten; Krause, Tyra Grove; Rasmussen, Morten; Michaelsen, Thomas Yssing; Voldstedlund, Marianne; Fonager, Jannik; Steenhard, Nina; Kirkeby, Carsten Thure; Danish Covid-19 Genome Consortium.

I: Nature Communications, Bind 12, 7251, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lyngse, FP, Mølbak, K, Skov, RL, Christiansen, LE, Mortensen, LH, Albertsen, M, Møller, CH, Krause, TG, Rasmussen, M, Michaelsen, TY, Voldstedlund, M, Fonager, J, Steenhard, N, Kirkeby, CT & Danish Covid-19 Genome Consortium 2021, 'Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load', Nature Communications, bind 12, 7251. https://doi.org/10.1038/s41467-021-27202-x

APA

Lyngse, F. P., Mølbak, K., Skov, R. L., Christiansen, L. E., Mortensen, L. H., Albertsen, M., Møller, C. H., Krause, T. G., Rasmussen, M., Michaelsen, T. Y., Voldstedlund, M., Fonager, J., Steenhard, N., Kirkeby, C. T., & Danish Covid-19 Genome Consortium (2021). Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load. Nature Communications, 12, [7251]. https://doi.org/10.1038/s41467-021-27202-x

Vancouver

Lyngse FP, Mølbak K, Skov RL, Christiansen LE, Mortensen LH, Albertsen M o.a. Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load. Nature Communications. 2021;12. 7251. https://doi.org/10.1038/s41467-021-27202-x

Author

Lyngse, Frederik Plesner ; Mølbak, Kåre ; Skov, Robert Leo ; Christiansen, Lasse Engbo ; Mortensen, Laust Hvas ; Albertsen, Mads ; Møller, Camilla Holten ; Krause, Tyra Grove ; Rasmussen, Morten ; Michaelsen, Thomas Yssing ; Voldstedlund, Marianne ; Fonager, Jannik ; Steenhard, Nina ; Kirkeby, Carsten Thure ; Danish Covid-19 Genome Consortium. / Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load. I: Nature Communications. 2021 ; Bind 12.

Bibtex

@article{a7e11899065a45788b1dd3e4c487a37b,

title = "Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load",

abstract = "New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.",

author = "Lyngse, {Frederik Plesner} and K{\aa}re M{\o}lbak and Skov, {Robert Leo} and Christiansen, {Lasse Engbo} and Mortensen, {Laust Hvas} and Mads Albertsen and M{\o}ller, {Camilla Holten} and Krause, {Tyra Grove} and Morten Rasmussen and Michaelsen, {Thomas Yssing} and Marianne Voldstedlund and Jannik Fonager and Nina Steenhard and Kirkeby, {Carsten Thure} and {Danish Covid-19 Genome Consortium}",

note = "Publisher Copyright: {\textcopyright} 2021. The Author(s).",

year = "2021",

doi = "10.1038/s41467-021-27202-x",

language = "English",

volume = "12",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

AU - Lyngse, Frederik Plesner

AU - Mølbak, Kåre

AU - Skov, Robert Leo

AU - Christiansen, Lasse Engbo

AU - Mortensen, Laust Hvas

AU - Albertsen, Mads

AU - Møller, Camilla Holten

AU - Krause, Tyra Grove

AU - Rasmussen, Morten

AU - Michaelsen, Thomas Yssing

AU - Voldstedlund, Marianne

AU - Fonager, Jannik

AU - Steenhard, Nina

AU - Kirkeby, Carsten Thure

AU - Danish Covid-19 Genome Consortium

PY - 2021

Y1 - 2021

N2 - New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

AB - New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

U2 - 10.1038/s41467-021-27202-x

DO - 10.1038/s41467-021-27202-x

M3 - Journal article

C2 - 34903718

AN - SCOPUS:85122774462

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 7251

ER -

ID: 296199866

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