Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis. / Bondesen, S; Nielsen, O H; Schou, J B; Jensen, P H; Lassen, L B; Binder, V; Krasilnikoff, P A; Danø, P; Hansen, S H; Rasmussen, S N.

I: Scandinavian Journal of Gastroenterology, Bind 21, Nr. 6, 1986, s. 693-700.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bondesen, S, Nielsen, OH, Schou, JB, Jensen, PH, Lassen, LB, Binder, V, Krasilnikoff, PA, Danø, P, Hansen, SH & Rasmussen, SN 1986, 'Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis', Scandinavian Journal of Gastroenterology, bind 21, nr. 6, s. 693-700.

APA

Bondesen, S., Nielsen, O. H., Schou, J. B., Jensen, P. H., Lassen, L. B., Binder, V., ... Rasmussen, S. N. (1986). Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis. Scandinavian Journal of Gastroenterology, 21(6), 693-700.

Vancouver

Bondesen S, Nielsen OH, Schou JB, Jensen PH, Lassen LB, Binder V o.a. Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis. Scandinavian Journal of Gastroenterology. 1986;21(6):693-700.

Author

Bondesen, S ; Nielsen, O H ; Schou, J B ; Jensen, P H ; Lassen, L B ; Binder, V ; Krasilnikoff, P A ; Danø, P ; Hansen, S H ; Rasmussen, S N. / Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis. I: Scandinavian Journal of Gastroenterology. 1986 ; Bind 21, Nr. 6. s. 693-700.

Bibtex

@article{3b094cb29f70440482bf51247963d7c1,
title = "Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis",
abstract = "Fifteen adult and 19 pediatric outpatients with ulcerative colitis were studied to determine the steady-state kinetics of 5-aminosalicylic acid (5-ASA) released from salazosulfapyridine (SASP). Results of excretion in adults (mean 24-h recovery of 5-ASA, 21{\%} in urine and 57{\%} in feces) were compatible with those of healthy volunteers. Since mean SASP dose/kg body weight (about 50 mg/kg) and compliance (reflected in sulfapyridine recovery) were equal in adults and pediatric patients, the results of the patient groups could be compared. Near-complete azo reduction of SASP occurs in children. Absorption and excretion of 5-ASA and metabolism to acetyl-5-ASA did not differ statistically between pediatric and adult patients. However, the fecal excretion of the drug and its metabolites was significantly lower in young patients, although fecal concentrations were the same. The present results demonstrate that SASP is an excellent sustained-release drug for the delivery of 5-ASA to the lower part of the bowel system and provide a reference for comparison of 5-ASA kinetics after treatment with newer 5-ASA preparations.",
keywords = "Adolescent, Adult, Aged, Aminosalicylic Acids/metabolism, Colitis, Ulcerative/drug therapy, Female, Humans, Kinetics, Male, Mesalamine, Middle Aged, Sulfanilamides/metabolism, Sulfapyridine/metabolism, Sulfasalazine/metabolism",
author = "S Bondesen and Nielsen, {O H} and Schou, {J B} and Jensen, {P H} and Lassen, {L B} and V Binder and Krasilnikoff, {P A} and P Dan{\o} and Hansen, {S H} and Rasmussen, {S N}",
year = "1986",
language = "English",
volume = "21",
pages = "693--700",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis

AU - Bondesen, S

AU - Nielsen, O H

AU - Schou, J B

AU - Jensen, P H

AU - Lassen, L B

AU - Binder, V

AU - Krasilnikoff, P A

AU - Danø, P

AU - Hansen, S H

AU - Rasmussen, S N

PY - 1986

Y1 - 1986

N2 - Fifteen adult and 19 pediatric outpatients with ulcerative colitis were studied to determine the steady-state kinetics of 5-aminosalicylic acid (5-ASA) released from salazosulfapyridine (SASP). Results of excretion in adults (mean 24-h recovery of 5-ASA, 21% in urine and 57% in feces) were compatible with those of healthy volunteers. Since mean SASP dose/kg body weight (about 50 mg/kg) and compliance (reflected in sulfapyridine recovery) were equal in adults and pediatric patients, the results of the patient groups could be compared. Near-complete azo reduction of SASP occurs in children. Absorption and excretion of 5-ASA and metabolism to acetyl-5-ASA did not differ statistically between pediatric and adult patients. However, the fecal excretion of the drug and its metabolites was significantly lower in young patients, although fecal concentrations were the same. The present results demonstrate that SASP is an excellent sustained-release drug for the delivery of 5-ASA to the lower part of the bowel system and provide a reference for comparison of 5-ASA kinetics after treatment with newer 5-ASA preparations.

AB - Fifteen adult and 19 pediatric outpatients with ulcerative colitis were studied to determine the steady-state kinetics of 5-aminosalicylic acid (5-ASA) released from salazosulfapyridine (SASP). Results of excretion in adults (mean 24-h recovery of 5-ASA, 21% in urine and 57% in feces) were compatible with those of healthy volunteers. Since mean SASP dose/kg body weight (about 50 mg/kg) and compliance (reflected in sulfapyridine recovery) were equal in adults and pediatric patients, the results of the patient groups could be compared. Near-complete azo reduction of SASP occurs in children. Absorption and excretion of 5-ASA and metabolism to acetyl-5-ASA did not differ statistically between pediatric and adult patients. However, the fecal excretion of the drug and its metabolites was significantly lower in young patients, although fecal concentrations were the same. The present results demonstrate that SASP is an excellent sustained-release drug for the delivery of 5-ASA to the lower part of the bowel system and provide a reference for comparison of 5-ASA kinetics after treatment with newer 5-ASA preparations.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aminosalicylic Acids/metabolism

KW - Colitis, Ulcerative/drug therapy

KW - Female

KW - Humans

KW - Kinetics

KW - Male

KW - Mesalamine

KW - Middle Aged

KW - Sulfanilamides/metabolism

KW - Sulfapyridine/metabolism

KW - Sulfasalazine/metabolism

M3 - Journal article

C2 - 2875518

VL - 21

SP - 693

EP - 700

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 6

ER -

ID: 218730765